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Notably, genes promoting glutathione biosynthesis were broadly upregulated, whereas genes associated with glutathione consumption or turnover were comparatively reduced ( Figure 6B )

Combined FOLFOX4 with all-trans retinoic acid versus FOLFOX4 with placebo in treatment of advanced hepatocellular carcinoma with extrahepatic metastasis: a randomized, double-blind comparative study

Kanai, Y

rs12325817) of the PEMT gene, which may affect the expression and/or activity of the PEMT enzyme, is thought to increase the susceptibility to choline deficiency-induced organ dysfunction (18)