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3 Research Service, San Diego VA Healthcare System, USA Allergy, Asthma & Clinical Immunology 2025, 21(Suppl 2) :P-58 Background: HAE patients may be vulnerable to the development of PTSD as a consequence of repeated unpredictable trauma associated with attacks of disfiguring swelling, severe abdominal pain, risk of asphyxiation or experiences with loss of a loved one with HAE